About: Application of DNA methylation arrays for assessment of aberrantly methylated genes in MDS and AML patients     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • Hematological malignancies, such as other malignancies, have specific epigenetic alterations of tumor suppressor genes, genes involved in differentiation, apoptosis, metastasis etc. The alterations of gene promoter methylation lead to uncontrolled proliferation of leukemic cells and malignant transformation. The DNA methylation changes can be used to detect leukemic cells in peripheral blood. We will examine the DNA methylation status of a wide spectrum of genes by the use of DNA methylation PCR arrays which allows us to observe multiple changes in gene methylation profile. These arrays are convenient for a more detail insight of epigenetic modifications occurring during the malignant transformation of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). We will choose the panel of the most promising genes based on our previous results from cultivation with demethylating agents such as Decitabine and on recently published data from genome-wide methylation studies. We will assess the (en)
  • Na základě našich předběžných výsledků a údajů z literatury chceme získat nové informace o epigenetické regulaci leukemogeneze AML a progrese MDS a tím přispět k individualizaci a zvýšení účinnosti léčby AML a MDS. (max.255 znaků) (cs)
Title
  • Application of DNA methylation arrays for assessment of aberrantly methylated genes in MDS and AML patients (en)
  • Studium aberantně metylovaných genů u pacientů s MDS a AML pomocí DNA metylačních arrayí. (cs)
http://linked.open...vai/cislo-smlouvy
http://linked.open...lsi-vedlejsi-obor
http://linked.open...avai/druh-souteze
http://linked.open...domain/vavai/faze
http://linked.open...vavai/hlavni-obor
http://linked.open...vai/vedlejsi-obor
http://linked.open...vavai/id-aktivity
http://linked.open.../vavai/id-souteze
http://linked.open...n/vavai/kategorie
http://linked.open...vai/klicova-slova
  • hypermethylation; tumor suppressor genes; epigenetics; minimal residual disease; demethylation drugs; DNA methylation array; MDS; AML (en)
http://linked.open...avai/konec-reseni
http://linked.open...nujicich-prijemcu
http://linked.open...avai/poskytovatel
http://linked.open...avai/start-reseni
http://linked.open...ai/statni-podpora
http://linked.open...vavai/typProjektu
http://linked.open...ai/uznane-naklady
http://linked.open...ai/pocet-prijemcu
http://linked.open...cet-spoluprijemcu
http://linked.open...ai/pocet-vysledku
http://linked.open...ku-zverejnovanych
is http://linked.open...ain/vavai/projekt of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 39 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software