About: Transplantation of the embryonic cerebellar tissue and stem cells into the cerebellum of Lurcher mutant and normal mice     Goto   Sponge   NotDistinct   Permalink

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  • Zkoumat dlouhodobé přežívání embryonální tkáně mozečku a neuroprogenitorů odvozených z nádorových kmenových buněk transplantovaných do mozečku mutantních myší Lurcher a normálních myší typu wild, zkoumat vliv transplantace na pohybové funkce myší Lrucher (cs)
  • The aim of the project is to investigate long-term survival of embryonic cerebellar tissue in the form of a solid graft or cell suspension and suspension of embryonic carcinoma stem cells-derived neuroprogenitors grafted into the cerebellum of adult Lurcher mutant and normal wild type mice and to examine the effect of transplantation on motor function of Lurcher mice. Lurcher mutant mice will be used as a natural model of hereditary olivocerebellar degeneration. Wild type mice will represent healthy controls. 2 and 6 months after surgery the mice will undergo a rotarod testing, gait examination and brain histological examination of presence and state of the graft. We will compare survival and possible functional effect of individual types of the grafts and their survival in Lurcher mice with affected cerebellum and in wild type mice with healthy cerebellum. Long-term survival and its functional manifestation 6 months after transplantation will be compared with those 2 months after the transplantation (en)
Title
  • Transplantation of the embryonic cerebellar tissue and stem cells into the cerebellum of Lurcher mutant and normal mice (en)
  • Transplantace embryonální tkáně mozečku a embryonálních nádorových kmenových buněk do mozečku normálních a mutantních myší Lurcher (cs)
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  • cerebellar ataxia; Lurchermutant mice; neurotransplantation; olivocerebellar degeneration (en)
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