About: Capillary leak syndrom. Importance for farmakokinetics and toxicokinetics of gentamicin.     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • Validovaná a reprodukovatelná experimentální metoda navození capillary leak syndromu u malého laboratorního zvířete spolu s kriteriemi objektivního vyhodnocení typu syndromu a jeho závažnosti. (cs)
  • Capillary leak syndrome (CLS) is characterized by an increase in vascular permeability accompained by extravasation of fluids and proteins from the capillary vessels into the tissues resulting in interstitial edema, decrease in microcirculatory pefusion and different types and severities of organ damage. CLS was observed in various pathological conditions- it occurs in patiens with sepsis, burns, trauma, surgery and other disease, in cancer patients treated with interleukon -2,-3-4, immunotoxins, GM-CSF, and cytostatics. Recently we have found that CLS in 37% of neonates critically ill treated with gentamicin (Ge) during the first postnatal week, CLS makes kinetically guided Ge dosage prediction impossible. It may be due to significant changes in the PK of Ge that is distributed to extravascular fluid and eliminated via glomerular filtration, and whose efficacy, moreover, is more dependent on plasma concentration than on the dosing. The project is focused on 1. development of experimental CLS, 2. (en)
Title
  • Capillary leak syndrome a jeho význam pro kinetiku a dynamiku modelových léčiv. (cs)
  • Capillary leak syndrom. Importance for farmakokinetics and toxicokinetics of gentamicin. (en)
http://linked.open...vai/cislo-smlouvy
http://linked.open...lsi-vedlejsi-obor
http://linked.open...avai/druh-souteze
http://linked.open...domain/vavai/faze
http://linked.open...vavai/hlavni-obor
http://linked.open...vai/vedlejsi-obor
http://linked.open...vavai/id-aktivity
http://linked.open.../vavai/id-souteze
http://linked.open...n/vavai/kategorie
http://linked.open...vai/klicova-slova
  • Capillary leak syndrome; experimental methods; pharmacokinetics of gentamicin (en)
http://linked.open...avai/konec-reseni
http://linked.open...nujicich-prijemcu
http://linked.open...avai/poskytovatel
http://linked.open...avai/start-reseni
http://linked.open...ai/statni-podpora
http://linked.open...vavai/typProjektu
http://linked.open...ai/uznane-naklady
http://linked.open...ai/pocet-prijemcu
http://linked.open...cet-spoluprijemcu
http://linked.open...ai/pocet-vysledku
http://linked.open...ku-zverejnovanych
is http://linked.open...ain/vavai/projekt of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 112 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software