About: Development of Novel Antituberculosis Agents and Prodrugs Effective against Multidrug Resistant Tuberculosis     Goto   Sponge   NotDistinct   Permalink

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  • Cílem projektu je modelování, syntéza a biologické hodnocení in vitro nových antituberkuloticky aktivních léčiv a jejich prodrug forem, hledání nových mechanismů účinku, aby splňovaly požadovaná kriteria (aktivitu, minimální multilékovou rezistenci, co nejméně vedlejších účinků a vysoký index selektivity). (cs)
  • Our investigation is based on molecular modelling of new anti-tuberculosis drugs and prodrugs, their synthesis, antimycobacterial activity evaluation in vitro and searching for new mechanisms of activity. The aim of the research is the cooperation in the synthesis of new antibacterial active compounds possessing select criteria (activity, minor multi drug resistance, minimum of side effects, high index selectivity) that would make them suitable for preclinical evaluation. (en)
Title
  • Development of Novel Antituberculosis Agents and Prodrugs Effective against Multidrug Resistant Tuberculosis (en)
  • Vývoj nových perspektivních antituberkulotik a jejich proléčiv aktivních vůči multirezistentním kmenům (cs)
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  • Prodrug; antimycobacterial activity; MDR strains of tuberculosis (en)
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