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Description
  • Vývoj nových přístupů ke kvantitativní analýze kapilárních sítí a jejich prostorového uspořádání pro porovnání kapilárního řečiště v různých oblastech krysího mozku vystaveného různým dávkám protonového záření či proudu těžkých iontů železa. (cs)
  • The project aims to develop novel interdisciplinary approaches to quantitative analysis of capillary networks and their spatial arrangement and introduce a detailed, step-by-step program providing a rigorous tool for comparison of capillary beds in different compartments of rat brain, irradiated with different doses of proton or Iron-56 radiation. Special methods for image pre-processing, segmentation and analysis of three-dimensional (3D) digital images of capillaries acquired by a confocal microscope will be developed. 3D arrangement of capillary bed in gray matter (cortex) and white matter (e.g. corpus callosum) will be studied by visualization of 3D image data acquired by a confocal microscope using interactive, semi-automatic and/or automatic approach based on computer reconstructions and virtual reality. The project addresses several challenging problems, such as the development of new approaches to segmentation of confocal image data, analysis of geometrical characteristics of capillary networ (en)
Title
  • Trojrozměrná analýza a vizualizace kapilární sítě v krysím mozku (cs)
  • Three-dimensional analysis and visualization of rat brain capillary network (en)
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  • 3D image analysis; 3D visualization; brain capillary bed; confocal microscopy; spatial statistics; proton radiation; Iron-56 radiation; stereology; virtual reality (en)
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