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  • 1. Charakteristika a eliminace hlavních determinant rezistence modelových nádorových buněčných linií odvozených od rakoviny prsu, tlustého střeva a slinivky (majoritní či obtížně léčitelné nádory) k apoptóze indukované ligandem TRAIL. 2. Optimalizace a potenciální využití receptor selektivních variant ligandu TRAIL analýza jimi aktivované signalizace v modelových rezistentních nádorových buňkách. (cs)
  • 1. Characterization and targeting of main resistance mechanism(s) to TRAIL-induced apoptosis in model cancer-derived cell lines of breast, colon and pancreatic origins (i.e. targeting some of the main/abundant and difficult-to-treat types of cancer). 2. Optimalization and potential use of TRAIL-receptor-specific variants of the recombinant ligand TRAIL analysis of their signaling in the model resistant cancer cell lines. (en)
Title
  • Analysis and suppression of mechanisms leading to the resistance of cancer cells to TRAIL. (en)
  • Analýza a potlačení mechanismů vedoucích k resistenci nádorových buněk k ligandu TRAIL. (cs)
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  • TRAIL; apoptosis; resistance; cancer cells; HTS screening; receptor-specific mutants of the ligand TRAIL (en)
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