About: The prediction of extension and risk profile of coronary atherosclerosis and their changes during lipid-lowering therapy based on non-invasive techniques.     Goto   Sponge   NotDistinct   Permalink

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  • The fundamental aim of this project is development of reliable algorithm for detection of extent and risk profile of coronary atherosclerosis based on non-invasive examinations (carotid ultrasound, examination of retinal vessel, diagnosis of endothelial dysfunction, pro-inflammatory markers including new markers of atherosclerosis and gene polymorphisms) with maximal effort on diagnosis of vulnerable plaques. The second part of the study is prediction of coronary atherosclerosis changes during high-dose lipid-lowering therapy (rosuvastatin 40 mg daily). Coronary artery impairment will be examined by up-to date technology using the fusion of angiography, intravascular ultrasound and virtual histology for 3D coronary artery reconstruction together with information about mechanical properties of arteries like a vessel shear stress. This algorithm for non-invasive assessment of coronary impairment and its changes during will be used for detection of high risk patients (in terms of acute coronary syndrom. (en)
  • 1/ Predikce rozsahu a rizikového profilu koronární aterosklerózy na základě klinického vyšetření a neinvazivních zobrazovacích metod (do 2014). 2/ Predikce změn rozsahu a rizikového profilu koronární aterosklerózy na základě změn v neinvazivních vyšetřeních (do 2015). 3/ Zhotovení 3D rekonstrukcí koronárních tepen a detailní analýza vzájemných vztahů mezi objemem plátu, složením plátu a WSS a jejich změn během podávání rosuvastatinu v dávce 40mg (do 2014). 4/ Zhodnocení vlivu WSS na rozvoj koronární aterosklerózy a jeho změny při hypolipidemické terapii (do 2014). (cs)
Title
  • The prediction of extension and risk profile of coronary atherosclerosis and their changes during lipid-lowering therapy based on non-invasive techniques. (en)
  • Predikce rozsahu a rizikovosti koronárního postižení a jejich změn při hypolipidemické terapii na základě neinvazivních vyšetření (cs)
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  • coronary atherosclerosis; prediction; atherosclerosis regression; intravascular ultrasound (en)
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