About: Multiparametric flow cytometry in study of malignant plasma cells pathophysiology

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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Description	Srovnání fenotypového profilu normálních a patologických plazmocytů pomocí multi/polychromatické průtokové cytometrie. Charakterizace a selekce plazmocytů za účelem jejich dalších analýz. Predikce rizika progrese/relapsu. Přínos flowcytometrie pro hodnocení minimální reziduální choroby. (cs) Immunophenotypisation of plasma cells using multiparametric flow cytometry brings enough data to define and distinguish heterogeneous population of neoplastic plasma cells from their normal equivalent. The aim of this project is to identify phenotypic profile in subjects with monoclonal gammopathy. The pathophysiology of plasma cells and changes in their behavior will be studied on cellular and molecular level to detect possible relationship between these changes and possibility of malignant transformation in monoclonal gammopathy of undetermined significance. This project can be used to identify new predictive and prognostic markers. They could lead to definite determination of diagnose, assessment of risk of progression in asymptomatic monoclonal gammopathies with consequent well-timed and accurately targeted treatment. The markers also could help to evaluate minimal residual disease and efficacy of treatment. (en)
Title	Multiparametric flow cytometry in study of malignant plasma cells pathophysiology (en) Uplatnění multiparametrické průtokové cytometrie ve studiu patofyziologie maligních plazmatických buněk (cs)
http://linked.open...vai/cislo-smlouvy	http://linked.opendata.cz/resource/domain/vavai/cep/smlouva/301/09/P457
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http://linked.open...vai/klicova-slova	monoklonální gamapatie; mnohočetný myelom; plazmatické buňky; průtoková cytometrie (en)
http://linked.open...avai/konec-reseni	2011-12-31 (xsd:date)
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http://linked.open...avai/start-reseni	2009-03-01 (xsd:date)
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is http://linked.open...ain/vavai/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2009/GP301/09/P457/orjk-14110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2010/GP301/09/P457/orjk-14110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2011/GP301/09/P457/orjk-14110

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