About: Betulinic acid derivatives, identification of mechanism of anticancer action based on expression profiling.

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About: Betulinic acid derivatives, identification of mechanism of anticancer action based on expression profiling. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
Description	Cílem projektu je uskutečnit expresní analýzu šesti cytotoxických derivátů kyseliny betulinové na nádorové linii CEM. Expresní profily budou porovnány s profily sandardních léčiv, diferenční data významně přispějí k pochopení mechanismu účinku a povedou k další validaci terapeutických cílů. (cs) Czech Republic is a country with a relatively high rate of cancer. The unsatisfactory results of anticancer therapy to date and the narrow spectrum of targeted drugs require active search for compounds with novel mechanisms of antitumour action. Our group is studying the mechanisms by which the triterpenoid compounds exert their cytotoxic effects. The most potent of these compounds induced apoptosis in a concentration less than IC50=0,2mM. We have identified cytochrome c as one unique target of b-keto betulinic acid. However, other potent compounds reveal a different kinetic of apoptosis induction with shifts in cell cycle distribution. Owing to the wide spectrum of possible targets we plan to use expression fingerprinting (profiling of mRNA/proteins) of a treated CEM cancer cell line. The expression profiles obtained will be compared to the profiles of drugs with identified mechanisms of action and further statistically analyzed. The differential data is expected to contribute to our understanding of the mechanism of action and facilitate target validation of triterpenoid compounds. (en)
Title	Deriváty kyseliny betulinové, identifikace mechanismů protinádorového účinku pomocí expresního profilování. (cs) Betulinic acid derivatives, identification of mechanism of anticancer action based on expression profiling. (en)
http://linked.open...vai/cislo-smlouvy	http://linked.opendata.cz/resource/domain/vavai/cep/smlouva/301/09/P433
http://linked.open...lsi-vedlejsi-obor	http://linked.opendata.cz/resource/domain/vavai/cep/obor/EB
http://linked.open...avai/druh-souteze	http://linked.opendata.cz/resource/domain/vavai/cep/druh-souteze/VS
http://linked.open...domain/vavai/faze	http://linked.opendata.cz/resource/domain/vavai/cep/faze/52807924
http://linked.open...vavai/hlavni-obor	http://linked.opendata.cz/resource/domain/vavai/cep/obor/FR
http://linked.open...vai/vedlejsi-obor	http://linked.opendata.cz/resource/domain/vavai/cep/obor/FD
http://linked.open...vavai/id-aktivity	http://linked.opendata.cz/resource/domain/vavai/cep/aktivita/GP
http://linked.open.../vavai/id-souteze	http://linked.opendata.cz/resource/domain/vavai/cep/soutez/SGA02009GA1PD
http://linked.open...n/vavai/kategorie	http://linked.opendata.cz/resource/domain/vavai/cep/kategorie/1
http://linked.open...vai/klicova-slova	mechanismus účinku, cytotoxicita, protinádorová terapie, betulinová kyselina (en)
http://linked.open...avai/konec-reseni	2011-12-31 (xsd:date)
http://linked.open...nujicich-prijemcu	0 (xsd:integer)
http://linked.open...avai/poskytovatel	http://linked.opendata.cz/resource/domain/vavai/cep/poskytovatel/GA0
http://linked.open...avai/start-reseni	2009-01-01 (xsd:date)
http://linked.open...ai/statni-podpora	1167 (xsd:integer)
http://linked.open...vavai/typProjektu	http://linked.opendata.cz/resource/domain/vavai/cep/typ/P
http://linked.open...ai/uznane-naklady	1167 (xsd:integer)
http://linked.open...ai/pocet-prijemcu	1 (xsd:integer)
http://linked.open...cet-spoluprijemcu	0 (xsd:integer)
http://linked.open...ai/pocet-vysledku	3 (xsd:integer)
http://linked.open...ku-zverejnovanych	3 (xsd:integer)
is http://linked.open...ain/vavai/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2009/GP301/09/P433/orjk-15110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2010/GP301/09/P433/orjk-15110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2011/GP301/09/P433/orjk-15110

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