About: Mouse models for investigation of biological functions of novel Kazal-type protease inhibitors LEKTI-2 and LEKTI-3

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About: Mouse models for investigation of biological functions of novel Kazal-type protease inhibitors LEKTI-2 and LEKTI-3 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
Description	Desquamation of the epidermis, a process that is dependent on serine proteases and their inhibitors, is fundamental for maintaining the barrier function of the skin. The proteases responsible for this process are kallikreins whose activity is balanced byKazal-type inhibitor LEKTI. Mutations in the gene encoding LEKTI causes Netherton-Syndrome characterized by disruption of the skin barrier. Currently, the group of Prof. J.M. Schröder discovered new Kazal-type inhibitors designated LEKTI-2 and -3 that are abundant in keratinocytes and inhibit kallikreins (KLK) 7 and 5, respectively. In cooperation, we aim to investigate the pathophysiologic function of LEKTIs in the skin barrier using mutant mice. To accomplish this goal, transgenic (tg) and deficientmice will be generated. To examine the inhibitory capacity of LEKTIs we will generate also tg mice expressing KLK5 and 7 in the epidermis, which will be treated with retroviral vectors expressing LEKTIs.Characterization of the role of LEKTI-2 and -3 may (en) Deskvamace epidermis představuje proces nepostradatelný pro ochrannou funkci kůže, který je závislý na serinových proteazách a jejich inhibitorech. Za tento process jsou odpovědné jsou kalilkreiny, jejichž aktivita je regulována Kazálním typem inhibitoruLEKTI. Mutace v genu SPINK5 kódující LEKTI vedou k vytvoření syndromu Netherton, který se projevuje narušením bariérové funkce kůže. Skupina Prof. J.M. Schrödera objevila nové inhibitory typu Kazal a pojmenovala je LEKTI-2 a -3. Tyto inhibitory jsou silně exprimovány v keratinocytech a inhibují kalikreiny (KLK) 5 a 7. V kooperaci bude naše skupina zkoumat patologickou a fyziologickou funkci LEKTI-2 a -3 za použití myších mutantů. K tomuto cíli, plánujeme vytvořit trangenní (tg) a deficientní (knock-out) myši. Dále budou vytvořeny trangenni myši exprimující KLK5 a 7 v epidermis, aby bylo možno analyzovat inhibiční potenciál inhibitorů. Tyto myší modely pak budou ošetřeny hybridními retroviry exprimující inhibitory LEKTI.Charakterizace (cs)
Title	Myší modely ke studiu biologické funkce nových proteázových inhibitorů typu Kazal LEKTI-2 a LEKTI-3 (cs) Mouse models for investigation of biological functions of novel Kazal-type protease inhibitors LEKTI-2 and LEKTI-3 (en)
http://linked.open...vai/cislo-smlouvy	http://linked.opendata.cz/resource/domain/vavai/cep/smlouva/301/08/J053
http://linked.open...lsi-vedlejsi-obor	http://linked.opendata.cz/resource/domain/vavai/cep/obor/FO
http://linked.open...avai/druh-souteze	http://linked.opendata.cz/resource/domain/vavai/cep/druh-souteze/VS
http://linked.open...domain/vavai/faze	http://linked.opendata.cz/resource/domain/vavai/cep/faze/53249670
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http://linked.open.../vavai/id-souteze	http://linked.opendata.cz/resource/domain/vavai/cep/soutez/SGA02008GA1GC
http://linked.open...n/vavai/kategorie	http://linked.opendata.cz/resource/domain/vavai/cep/kategorie/1
http://linked.open...vai/klicova-slova	epidermis; inhibitor; serine protease; transgenic mouse; knockout (gene-deficient mouse); tissue-spe (en)
http://linked.open...avai/konec-reseni	2010-12-31 (xsd:date)
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http://linked.open...avai/poskytovatel	http://linked.opendata.cz/resource/domain/vavai/cep/poskytovatel/GA0
http://linked.open...avai/start-reseni	2008-01-01 (xsd:date)
http://linked.open...ai/statni-podpora	4482 (xsd:integer)
http://linked.open...vavai/typProjektu	http://linked.opendata.cz/resource/domain/vavai/cep/typ/P
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is http://linked.open...ain/vavai/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2008/GC301/08/J053/ico-68378050 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2009/GC301/08/J053/ico-68378050 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2010/GC301/08/J053/ico-68378050 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2011/GC301/08/J053/ico-68378050

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