About: Impact of different topology of heterologous antigenic determinants in PVX-based plant viral vector on their expression level and immunogenicity     Goto   Sponge   NotDistinct   Permalink

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  • Předkládaný projekt je zaměřen na zvýšení stability a imunogenity cizorodých epitopů produkovaných v rostlinách pomocí vektoru založeného na X viru bramboru (PVX) za účelem vývoje experimentální vakcíny. Bude posouzen vliv topologie imunodominantního E7 epitopu odvozeného z onkoproteinu lidského papillomaviru typu 16 (HPV16) umístěného ve čtyřech povrchových smyčkách spojujících alfa-helixy a beta-skládané listy ve struktuře kapsidového proteinu PVX (PVX CP), o kterých se předpokládá, že jsou lokalizovány na povrchu částic tvořených PVX CP. Konstrukty budou připraveny v různém uspořádání a bude posouzen vliv různého umístění epitopu v PVX CP na hladinu jeho exprese, tvorbu částic a imunogenitu. (cs)
  • The current project will be undertaken with the aim of strengthening the stability of heterologous epitopes produced in plants using a viral vector based on Potato virus X (PVX) and improving the immunogenic capabilities of this particular antigen-producing system for the purposes of experimental vaccine development. The ability of the PVX-based vector to support the expression of an epitope in the dependence on its location in different positions situated on the surface of the PVX coat protein (CP) will be studied. We propose the production of the immunodominant epitope derived from the human papillomavirus type 16 E7 oncoprotein situated in four different locations in the loops connecting alpha-helices and beta-strands which are assumed to be located on the exterior part of PVX-CP particles. We will focus on different arrangement of these constructs. Simultaneously we will evaluate the influence of the position of the inserted epitope on its expression level, formation of particles, and immunogenicity. (en)
Title
  • Impact of different topology of heterologous antigenic determinants in PVX-based plant viral vector on their expression level and immunogenicity (en)
  • Vliv topologie heterologních antigenních determinant ve vektoru odvozeném od X viru bramboru (PVX) na jejich expresi v rostlinách a imunogenitu (cs)
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  • transient expression; heterologous antigenic determinant; plant viral vector (en)
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