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  • Insect bite hypersensitivity in horses is allergic disorder that arises from hypersensitivity reactions to insect bite. The immune response  is polarized to Th2 in IBH. Genetic architecture of allergic disorders in horses  is not quite explored.  Except for genes playing role in allergic disorders in  general - IgE,  FCER and  inflammatory mediators genes,  there are genes of Th2  immune response included in IBH.  Local skin  defects  appear in IBH,  that is why the effort is concentrated  on genes taking part in  a skin structure  and  skin immunity  mechanisms. The general goal of the project is  the study of  the genetic basis   of immunity mechanisms in IBH in Old Kladruber horses. There were  found significant associations  of microsatellite AHT4 and  I18 with IBH in our previous project.  The specific aim is to identify   new   candidate genes   in  associated chromosomal regions  and to confirm the associations of previously reported candidate genes, including selected pathways in horses.  The validation   of  results in another breed will be performed - in the model Icelandic horse population. The gene expression comparison  in affected and healthy  horses will be used  to  validate markers in confirmed associations. (en)
  • Cílem projektu je detailní charakterizace kandidátních chromozomálních oblastí pro IBH v modelové populaci Starokladrubských koní a identifikace kandidátních genů pro toto onemocnění. (cs)
Title
  • Immunogenomic analysis of insect bite hypersensitivity in the Old Kladruber horse (en)
  • Imunogenomická analýza letní dermatitidy u Starokladrubských koní (cs)
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  • kandidátní geny; alergie; kůň (en)
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