About: Molecular sources of centrosomal abnormalities in human embryonic stem cells     Goto   Sponge   NotDistinct   Permalink

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  • Cílem projektu je pochopení molekulárních mechanismů, které podmiňují vznik chromozomálních abnormalit v lidských embryonálních kmenových buňkách. Získání těchto poznatků nejen doplní poznání biologie tohoto unikátního buněčného typu, ale současně přispěje k odhalení mechanismů kancerogeneze. (cs)
  • Human embryonic stem (ES) cells are cell lines derived from normal human preimplantation embryos. Thanks to their proliferative and differentiation potential these cells represent the tool for cell therapies and for analysis of molecular mechanisms underlying human diseases. Human ES cells can be propagated in vitro for long periods of time, however, they tend to harbor multiple genetic changes, which seem to underlie their adaptation to culture but are not understood from mechanistic and biological point of view. Our recent experiments show that human ES cells are affected by centrosomal abnormalities and do possess unusual molecular features that may contribute to such phenomenon.  In this project we will use genetic approaches (transgenesis, RNA inhibition) to modulate expression/function of molecular players involved in these features to determine their significance for centrosomal aberations.  By this we will unravel mechanisms that are responsible for chromosomal changes in human ES cells and also contribute to understanding cancer-associated genetic instability. (en)
Title
  • Molekulární zdroje centrozomálních abnormalit u lidských embryonálních kmenových buněk (cs)
  • Molecular sources of centrosomal abnormalities in human embryonic stem cells (en)
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  • lidské embryonální kmenové buňky; genetická stabilita; centrozom; kinázy (en)
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