About: Macrocyclic ligands suitable for development of new radiopharmaceuticals based on metal isotopes

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About: Macrocyclic ligands suitable for development of new radiopharmaceuticals based on metal isotopes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
Description	Polyazacyclesless and/or unsymetrically substituted with phosphorus acid pendant arms willbe synthesized and their coordination ability toward di-/tri-valent metal ionswill be investigated. Complexes of the ligands should retain convenientproperties of such complexes of analogous carboxylic ligands (thermodynamic/kinetic stability) butshould provide some improved physico-chemical properties as complexation rates.Thermodynamic, kinetic and spectroscopic properties of these compounds will beinvestigated under chemical conditions. Selected ligands/complexes will beinvestigated under radiochemical conditions (complexation, stability).Compounds with desired properties (suitable for use in nuclear medicine fordiagnosis/therapy) will be investigated in vitro or in vivo and conjugated tobiological vectors. The main aim of the Project is an understanding how aligand structure (size of macrocycle, number and/or kind of pendant arms,placement of the pendant arms) influences properties of the complexes formedand how the properties are altered on a way from the low-molecular-weightcomplexes to larger organized systems. An import part consists from a developmentof technology for use of suitable isotopes and complexes as newradiopharmaceuticals. (en) Cílem je lepší porozumění zákonitostem, jak struktura ligandu (velikost kruhu; počet, typ nebo umístění pendantů) ovlivňuje vlastnosti jejich komplexů, které jsou podstatné pro jejich možné využití v nukleární medicíně; příprava technologie pro možná radiofarmaka založená na těchto ligandech. (cs)
Title	Macrocyclic ligands suitable for development of new radiopharmaceuticals based on metal isotopes (en) Makrocyklické ligandy vhodné pro vývoj nových radiofarmak založených na izotopech kovů (cs)
http://linked.open...vai/cislo-smlouvy	http://linked.opendata.cz/resource/domain/vavai/cep/smlouva/203/09/1056
http://linked.open...lsi-vedlejsi-obor	http://linked.opendata.cz/resource/domain/vavai/cep/obor/FP
http://linked.open...avai/druh-souteze	http://linked.opendata.cz/resource/domain/vavai/cep/druh-souteze/VS
http://linked.open...domain/vavai/faze	http://linked.opendata.cz/resource/domain/vavai/cep/faze/52808251
http://linked.open...vavai/hlavni-obor	http://linked.opendata.cz/resource/domain/vavai/cep/obor/CA
http://linked.open...vai/vedlejsi-obor	http://linked.opendata.cz/resource/domain/vavai/cep/obor/CH
http://linked.open...vavai/id-aktivity	http://linked.opendata.cz/resource/domain/vavai/cep/aktivita/GA
http://linked.open.../vavai/id-souteze	http://linked.opendata.cz/resource/domain/vavai/cep/soutez/SGA02009GA-ST
http://linked.open...n/vavai/kategorie	http://linked.opendata.cz/resource/domain/vavai/cep/kategorie/1
http://linked.open...vai/klicova-slova	makrocykly; radionuklidy kov; terodynamická a kinetická stabilita; radiofarmaka (en)
http://linked.open...avai/konec-reseni	2011-12-31 (xsd:date)
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http://linked.open...avai/poskytovatel	http://linked.opendata.cz/resource/domain/vavai/cep/poskytovatel/GA0
http://linked.open...avai/start-reseni	2009-03-01 (xsd:date)
http://linked.open...ai/statni-podpora	2884 (xsd:integer)
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is http://linked.open...ain/vavai/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2009/GA203/09/1056/ico-61389005 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2009/GA203/09/1056/orjk-11310 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2010/GA203/09/1056/ico-61389005 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2010/GA203/09/1056/orjk-11310 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2011/GA203/09/1056/ico-61389005 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2011/GA203/09/1056/orjk-11310

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