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  • Tabulka 1: Průměrné (SD) farmakokinetické parametry Loette během 21 denního dávkovacího režimu LNG Cmax Tmax AUC CL/F Vλz/F SHBG Den ng/ml h ng·h/ml ml/h/kg l/kg nmol/l 1 2,75 (0,88) 1,6 (0,9) 35,2 (12,8) 53,7 (20,8) 2,66 (1,09) 57 (18) 6 4,52 (1,79) 1,5 (0,7) 46,0 (18,8) 40,8 (14,5) 2,05 (0,86) 81 (25) 21 6,00 (2,65) 1,5 (0,5) 68,3 (32,5) 28,4 (10,3) 1,43 (0,62) 93 (40) Volný LNG Den pg/ml h pg·h/ml l/h/kg l/kg fn % 1 51,2 (12,9) 1,6 (0,9) 654 (201) 2,79 (0,97) 135,9 (41,8) 1,92 (0,30) 6 77,9 (22,0) 1,5 (0,7) 794 (240) 2,24 (0,59) 112,4 (40,5) 1,80 (0,24) 21 103,6 (36,9) 1,5 (0,5) 1177 (452) 1,57 (0,49) 78,6 (29,7) 1,78 (0,19) EE Den pg/ml h pg·h/ml ml/h/kg l/kg 1 62,0 (20,5) 1,5 (0,5) 653 (227) 567 (204) 14,3 (3,7) 6 76,7 (29,9) 1,3 (0,7) 604 (231) 610 (196) 15,5 (4,0) 21 82,3 (33,2) 1,4 (0,6) 776 (308) 486 (179) 12,4 (4,1) Cl/F – clearance perorální dávky; (cs)
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