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salt:hasText	Použití v kombinaci při léčbě karcinomu močového měchýře Nežádoucí účinky stupně 3 a 4 MVAC versus gemcitabin + cisplatina Počet (%) pacientů MVAC (methotrexát, vinblastin, doxorubicin a cisplatina) (N = 196) gemcitabin + cisplatina (N = 200) stupeň 3 stupeň 4 stupeň 3 stupeň 4 Laboratorní anemie 30 (16) 4 (2) 47 (24) 7 (4) trombocytopenie 15 (8) 25 (13) 57 (29) 57 (29) Nelaboratorní nauzea a zvracení 37 (19) 3 (2) 44 (22) 0 (0) průjem 15 (8) 1 (1) 6 (3) 0 (0) infekce 19 (10) 10 (5) 4 (2) 1 (1) stomatitida 34 (18) 8 (4) 2 (1) 0 (0) Použití v kombinaci při léčbě karcinomu ovaria Nežádoucí účinky stupně 3 a 4 karboplatina versus gemcitabin + karboplatina Počet (%) pacientů karboplatina (N = 174) gemcitabin+karboplatina (N = 175) stupeň 3 stupeň 4 stupeň 3 stupeň 4 Laboratorní anemie 10 (5,7) 4 (2,3) 39 (22,3) 9 (5,1) neutropenie 19 (10,9) 2 (1,1) 73 (41,7) 50 (28,6) trombocytopenie 18 (10,3) 2 (1,1) 53 (30,3) 8 (4,6) leukopenie 11 (6,3) 1 (0,6) 84 (48,0) 9 (5,1) Nelaboratorní krvácení 0 (0,0) 0 (0,0) 3 (1,8) 0 (0,0) febrilní neutropenie 0 (0,0) 0 (0,0) 2 (1,1) 0 (0,0) infekce bez neutropenie 0 (0,0) 0 (0,0) 0 (0,0) 1 (0,6) Senzorická neuropatie byla také častější ve skupině kombinované léčby oproti skupině samotné karboplatiny. (cs)
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