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  • 19) AUC0-∞ (mg.h/l) 25,4 ± 4,32 - - AUC12h (mg . h/l) - 38,2 ± 42,7 30,1 ± 15,1 Cmax ((g/ml) 9,03± 1,26 12,9 ± 21,5 5,44 ± 4,04 t1/2 (h) 3,32 ± 0,47 2,52 ± 0,55 2,98 ± 1,26 GAN = Ganciklovir, i.v. VAL = Valganciklovir, perorálně Farmakokinetické modelování prokázalo, že u novorozenců byla typická hodnota clearance (l/h) 0,146 x tělesná hmotnost1,68, distribuční objem (l) 1,15 x tělesná hmotnost a biologická dostupnost gancikloviru 54 %. (cs)
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