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  • U pacientů s chronickou renální insuficiencí, srdeční nedostatečností a jaterní insuficiencí a také v situacích změn objemu plazmatické tekutiny může vést redukce syntézy prostaglandinů k akutnímu ledvinnému selhání, retenci tekutin a srdečnímu selhání (viz body 4.3. a 4.4.). (cs)
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