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  • 5.1. Farmakodynamické vlastnosti (cs)
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  • 005.001
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  • Farmakoterapeutická skupina: makrolidové antibiotikum ATC kód: J01FA10 Azithromycin je azalidové antibiotikum, podtřída makrolidových antibiotik. Vazbou na ribozomální podjednotku 50S brání translokaci peptidového řetězce z jedné strany ribozomu na druhý a tím brání RNA-dependentní proteosyntéze u citlivých organizmů. Azithromycin má široké spektrum účinnosti, působí na různé gram-pozitivní a gram-negativní bakterie, anaerobní, intracelulární a klinicky atypické mikroorganismy. MIC90 ( 0,01 (g/ml Haemophilus ducreyi Mycoplasma pneumoniae MIC90 0,01-0,1 (g/ml Actinomyces species Bordetella pertussis Borrelia burgdorferi Gardnerella virginalis Mobiluncus species Moraxella catarrhalis Propionibacterium acnes MIC90 0,01-2,0 (g/ml Bacteriodes bivius Bordetella parapertussis Brucella melitensis Campylobacter jejuni Clostridium perfringens Fusobacterium necrophorum Haemophilus influenzae Haemophilus parainfluenzae Helicobacter pylori Chlamydia pneumoniae Chlamydia trachomatis Legionella pneumophila Listeria monocytogenes Neisseria gonorrhoeae Neisseria meningitidis Pasteurella haemolytica Pasteurella multocida Peptococcus species Peptostreptococcus Plesiomonas shigelloides Staphylococcus aureus Streptococcus agalactiae Staphylococcus epidermidis Streptococcus pneumoniae Streptococcus pyogenes Streptococcus viridans streptokoky skupiny C, F, G Ureaplasma urealyticum Vibrio cholerae Vibrio parahaemolyticus MIC90 2,0-8,0 (g/ml Acinetobacter calcoaceticus Aeromonas hydrophylia Bacteroides fragilis Bacteroides oralis Clostridium difficile Escherichia coli Eubacterium lentum Fusobacterium nucleatum Salmonella enteritidis Salmonella typhi Shigella sonnei Yersinia enterocolitica MIC90 > 10 (g/ml Citrobacter species Corynebacterium species Enterobacter aerogenes Enterobacter cloacae Enterococcus faecalis Enterococcus faecium Eubacterium limosum Klebsiella pneumoniae Klebsiella oxytoca Mycoplasma hominis Proteus species Pseudomonas aeruginosa Serratia marcescens (cs)
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