About: Oral Aminolevulinic Acid Hydrochloride

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About: Oral Aminolevulinic Acid Hydrochloride Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Oral Aminolevulinic Acid Hydrochloride
rdfs:subClassOf	Photosensitizing Agent
Semantic_Type	Pharmacologic Substance
Preferred_Name	Oral Aminolevulinic Acid Hydrochloride
NCI_META_CUI	CL433488
PDQ_Open_Trial_Search_ID	723865
PDQ_Closed_Trial_Search_ID	723865
FULL_SYN	Oral Aminolevulinic Acid HydrochloridePTNCI GliolanFBNCI 5-Aminolevulinic Acid Hydrochloride, OralSYNCI Oral 5-ALAABNCI
DEFINITION	A powder for an oral solution comprised of the hydrochloride salt of 5-aminolevulinic acid (ALA) with a potential application for photodynamic therapy. After oral administration, ALA is converted intracellularly into the photosensitizer protoporphyrin IX (PpIX). Upon exposure to light of appropriate wavelength (violet to blue range), excited PpIX emits a characteristic red fluorescence which could facilitate guided resection, and generates excited singlet oxygen molecules that could kill cells when appropriate laser dosage is applied. ALA is preferentially taken up by and accumulates in many types of cancer cells compared to normal, healthy cells. Consequently, cancer cells can be visualized and can be distinguished from normal, healthy cells.NCI
code	C99763

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