About: FIP1L1/PDGFRA Fusion Protein     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • FIP1L1/PDGFRA Fusion Protein
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • FIP1L1/PDGFRA Fusion Protein
NCI_META_CUI
  • CL433476
FULL_SYN
  • Pre-mRNA 3'-End-Processing Factor FIP1/Alpha-Type Platelet-Derived Growth Factor Receptor Fusion ProteinSYNCI
  • FIP1L1-PDGFRA Fusion ProteinSYNCI
  • FIP1L1/PDGFRA Fusion ProteinPTNCI
DEFINITION
  • A fusion protein (849, ~95 kDa) encoded by the FIP1L1/PDGFRA fusion gene. This protein is comprised of the first 339 amino acids of pre-mRNA 3'-end-processing factor FIP1, fused to the C-terminal cytoplasmic domains of the alpha-type platelet-derived growth factor receptor protein, including the protein kinase domain.NCI
DesignNote
  • The FIP1L1/PDGFRA fusion protein is a constitutively activated tyrosine kinase because of a disruption of the juxtamembrane kinase regulatory domain of the alpha-type platelet-derived growth factor receptor protein. (OMIM)
code
  • C99744
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