About: CRTC1/MAML2 Fusion Protein     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CRTC1/MAML2 Fusion Protein
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • CRTC1/MAML2 Fusion Protein
NCI_META_CUI
  • CL433475
FULL_SYN
  • MECT1/MAML2 Fusion ProteinSYNCI
  • CRTC1/MAML2 Fusion ProteinPTNCI
  • TORC1-MAML2 Fusion ProteinSYNCI
  • WAMTP1-MAML2 Fusion ProteinSYNCI
  • CREB-Regulated Transcription Coactivator 1/Mastermind-Like Protein 2 Fusion ProteinSYNCI
  • CRTC1-MAML2 Fusion OncoproteinSYNCI
DEFINITION
  • A fusion protein (1024 aa, ~112 kDa) encoded by the CRTC1/MAML2 fusion gene. This protein is comprised of the first 42 N-terminal amino acids of the CREB-regulated transcription coactivator 1 protein fused to most of the mastermind-like protein 2.NCI
DesignNote
  • The CRTC1/MAML2 fusion protein activates transcription of the Notch target gene HES1 independently of both Notch ligand and CSL. (Atlas of Genetics and Cytogenetics in Oncology and Haematology)
code
  • C99742
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