About: Capecitabine Rapidly Disintegrating Tablet     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Capecitabine Rapidly Disintegrating Tablet
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Capecitabine Rapidly Disintegrating Tablet
NCI_META_CUI
  • CL433297
PDQ_Open_Trial_Search_ID
  • 721986
PDQ_Closed_Trial_Search_ID
  • 721986
FULL_SYN
  • Capecitabine Rapidly Disintegrating TabletPTNCI
  • Capecitabine RDTSYNCI
DEFINITION
  • A rapidly disintegrating film-coated tablet composed of the fluoropyrimidine carbamate antimetabolite capecitabine with antineoplastic activity. As a prodrug, capecitabine is converted to 5'-deoxy-5-fluorocytidine (5'-DFCR) by hepatic carboxylesterase and then to 5'-deoxy-5-fluorouridine (5'-DFUR) by cytidine deaminase and is eventually activated by thymidine phosphorylase to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine triphosphate production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand. Capecitabine rapidly disintegrating tablet (RDT) contains the water insoluble, disintegrating agent crospovidone which very rapidly disperses and swells in water making this RDT easier to swallow than the traditional capecitabine tablet.NCI
code
  • C99629
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