About: ETV6/JAK2 Fusion Protein     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • ETV6/JAK2 Fusion Protein
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • ETV6/JAK2 Fusion Protein
NCI_META_CUI
  • CL433190
FULL_SYN
  • TEL/JAK2 Fusion ProteinSYNCI
  • ETV6-JAK2 Fusion ProteinSYNCI
  • ETV6/JAK2 Fusion ProteinPTNCI
  • Transcription Factor ETV6/Tyrosine-Protein Kinase JAK2 Fusion ProteinSYNCI
DEFINITION
  • A fusion protein encoded by the ETV6/JAK2 fusion gene. This protein is comprised of the N-terminal half of the transcription factor ETV6 protein, including the pointed domain and the helix-loop-helix oligomerization domain, fused to the C-terminal tyrosine kinase domains of the tyrosine-protein kinase JAK2 protein.NCI
DesignNote
  • The helix-loop-helix domain of the transcription factor ETV6 protein may provide a dimerization interface for kinase domain of the tyrosine-protein kinase JAK2, which activates its tyrosine kinase activity. (Atlas of Genetics and Cytogenetics in Oncology and Haematology)
code
  • C99417
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