About: Monobenzone

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Monobenzone
rdfs:subClassOf	Hydrocarbons
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Monobenzone
NSC_Code	33918
UMLS_CUI	C0050962
CAS_Registry	103-16-2
Accepted_Therapeutic_Use_For	Vitiligo
FDA_UNII_Code	9L2KA76MG5
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	39494
PDQ_Closed_Trial_Search_ID	39494
Chemical_Formula	C13H12O2
Legacy_Concept_Name	Monobenzone
CHEBI_ID	CHEBI:34380
FULL_SYN	MonobenzoneSYDTPNSC0033918 monobenzyl ether of hydroquinoneSYNCI MonobenzonePTNCI MBEHABNCI Monobenzyl ether hydroquinoneSYDTPNSC0033918 Hydroquinone monobenzyl etherSYDTPNSC0033918 BenoquinBRNCI MONOBENZONEPTFDA9L2KA76MG5
DEFINITION	A monobenzyl ether of hydroquinone with topical depigmentation activity. Although the exact mechanism of action of depigmentation is unknown, the metabolites of monobenzone appear to have a cytotoxic effect on melanocytes. Furthermore, the depigmentation effect might be mediated through the inhibition of tyrosinase, which is essential in the synthesis of melanin pigments, thereby causing permanent depigmentation of the skin.NCI
code	C992

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