About: 2-O, 3-O Desulfated Heparin     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • 2-O, 3-O Desulfated Heparin
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • 2-O, 3-O Desulfated Heparin
NCI_META_CUI
  • CL432948
PDQ_Open_Trial_Search_ID
  • 715907
PDQ_Closed_Trial_Search_ID
  • 715907
FULL_SYN
  • 2-O, 3-O Desulfated HeparinPTNCI
  • ODSHABNCI
DEFINITION
  • A non-anticoagulant heparin derivative in which the 2-O and 3-O sulfate groups of heparin are removed, with potential anti-inflammatory and antineoplastic activity. Upon administration, 2-O, 3-O desulfated heparin (ODSH) prevents the interaction of the receptor for advanced glycation end-products (RAGE) to its ligands, such as advanced glycation end-products (AGEs), Mac-1(CD11b/CD18), the nuclear protein high mobility group box protein-1 (HMGB-1), carboxymethyl lysine-bovine serum albumin (CML-BSA) and members of the S100 calgranulin family. In addition, this agent inhibits the enzymes heparanase, cathepsin G, and human leukocyte elastase, which are involved in inflammation and metastasis. ODSH also inhibits selectins, thereby preventing the adhesion of tumor cells to endothelium and platelets. Altogether, this may inhibit tumor cell invasiveness and metastasis. Unlike heparin, this agent does not induce heparin-induced thrombocytopenia (HIT). RAGE, a receptor belonging to the immunoglobulin superfamily, plays a key role in inflammation and is overexpressed in a variety of cancers.NCI
code
  • C99130
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