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AttributesValues
rdf:type
rdfs:label
  • Acitretin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Acitretin
UMLS_CUI
  • C0678135
CAS_Registry
  • 55079-83-9
Accepted_Therapeutic_Use_For
  • Psoriasis; cutaneous T-cell lymphoma
In_Clinical_Trial_For
  • Prevention of skin cancer in patients with previously treated skin cancers who have undergone organ transplantation
FDA_UNII_Code
  • LCH760E9T7
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is used in the prevention of cancer and in the treatment of psoriasis. It belongs to the family of drugs called retinoids.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43244
PDQ_Closed_Trial_Search_ID
  • 43244
Chemical_Formula
  • C21H26O3
Legacy_Concept_Name
  • Acitretin
CHEBI_ID
  • CHEBI:50173
FULL_SYN
  • AcitretinPTDCP30398
  • Trimethylmethoxyphenyl-retinoic acidSYNCI
  • (All-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic AcidSNNCI
  • ACITRETINPTFDALCH760E9T7
  • EtretinSYNCI
  • AcitretinPTNCI
  • SoriataneBRNCI
  • Ro 10-1670CNNCI
  • Ro-10-1670CNNCI
  • acitretinPTNCI-GLOSSCDR0000046118
  • NeotigasonFBNCI
DEFINITION
  • An orally-active metabolite of the synthetic aromatic retinoic acid agent etretinate with potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties. Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis. (NCI04)NCI
code
  • C985
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