About: Sphingosine Kinase-2 Inhibitor ABC294640     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Sphingosine Kinase-2 Inhibitor ABC294640
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sphingosine Kinase-2 Inhibitor ABC294640
UMLS_CUI
  • C2933332
PDQ_Open_Trial_Search_ID
  • 712053
PDQ_Closed_Trial_Search_ID
  • 712053
FULL_SYN
  • SK2 inhibitor ABC294640SYNCI
  • Sphingosine Kinase-2 Inhibitor ABC294640PTNCI
  • ABC294640CNNCI
DEFINITION
  • An orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis and may result in an inhibition of cell proliferation in cancer cells overexpressing SK2. SK2 and its isoenzyme SK1 are overexpressed in numerous cancer cell types.NCI
code
  • C98278
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