About: Chloroquinoxaline Sulfonamide     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Chloroquinoxaline Sulfonamide
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Chloroquinoxaline Sulfonamide
NSC_Code
  • 339004
UMLS_CUI
  • C0049111
CAS_Registry
  • 97919-22-7
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. It is a type of topoisomerase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41055
PDQ_Closed_Trial_Search_ID
  • 41055
Legacy_Concept_Name
  • Chloroquinoxaline_Sulfonamide
FULL_SYN
  • ChlorsulfaquinoxalineSYNCI
  • CQSPTNCI-GLOSSCDR0000044381
  • chlorosulfaquinoxalineSYNCI
  • CQSABNCI
  • Benzenesulfonamide, 4-amino-N-(5-chloro-2-quinoxalinyl)-SNNCI
  • Benzenesulfonamide, 4-amino-N-[5-chloro-2-quinoxalinyl]-SYDTPNSC0339004
  • Chloroquinoxaline sulfonamideSYDTPNSC0339004
  • Chloroquinoxaline SulfonamidePTNCI
  • chloroquinoxaline sulfonamidePTNCI-GLOSSCDR0000045331
DEFINITION
  • A chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity. Chloroquinoxaline sulfonamide poisons topoisomerase II alpha and topoisomerase II beta, thereby causing double-stranded breaks in DNA, accumulation of unrepaired DNA, and apoptosis. This agent also exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner. (NCI04)NCI
code
  • C982
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