About: Recombinant Interferon Alpha 2b-like Protein     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Interferon Alpha 2b-like Protein
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Recombinant Interferon Alpha 2b-like Protein
NCI_META_CUI
  • CL430249
PDQ_Open_Trial_Search_ID
  • 703323
PDQ_Closed_Trial_Search_ID
  • 703323
FULL_SYN
  • Recombinant Interferon Alpha 2b-like ProteinPTNCI
  • Recombinant IFN Alfa-2b-like ProteinSYNCI
  • NovaferonBRNCI
DEFINITION
  • A proprietary recombinant protein highly resembling human interferon alpha 2b (IFN-a2b), with potential anti-tumor, anti-inflammatory, immunomodulating and antiviral activities. Upon injection, recombinant IFN alpha 2b-like protein binds to specific IFN alpha cell surface receptors. This activates interferon-mediated signal transduction pathways and induces the transcription and translation of genes with interferon-specific response elements (ISREs). This may activate the immune system, including the activation of natural killer cells (NKs) and may result in an inhibition of tumor cell proliferation, tumor angiogenesis, metastasis and an induction of apoptosis. Compared to human IFN-a2b (HuINF-a2b), this agent exhibits enhanced antiviral and antiproliferative activities. In addition, this agent exhibits antiviral activity against a variety of viruses, including hepatitis B and C viruses, human immunodeficiency virus (HIV) and Avian Influenza.NCI
code
  • C97503
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