About: 18F-labeled Mini-PEG Spacered RGD Dimer     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • 18F-labeled Mini-PEG Spacered RGD Dimer
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • 18F-labeled Mini-PEG Spacered RGD Dimer
NCI_META_CUI
  • CL429825
PDQ_Open_Trial_Search_ID
  • 703211
PDQ_Closed_Trial_Search_ID
  • 703211
FULL_SYN
  • [18F] FPRGD2ABNCI
  • 18F-labeled Mini-PEG Spacered RGD DimerPTNCI
  • (18)F-FB-mini-PEG-E[c(RGDyK)](2)SYNCI
  • 18F-FPRGD2ABNCI
DEFINITION
  • A radiotracer containing a pegylated dimeric Arg-Gly-Asp (RGD) peptide (NH2-mini-PEG-E[c(RGDyK)]2 or PRGD2) radiolabeled with fluorine 18F-fluorobenzoate (18F-FB), with potential alphaVbeta3 integrin imaging activity upon positron emission topography (PET). Upon administration, the RGD moiety of 18F-labeled Mini-PEG Spacered RGD Dimer (18F-FPRGD2) binds to alphaVbeta3 integrin. Upon PET, alphaVbeta3-expressing tumor cells can be visualized and the degree of tumor angiogenesis can be determined. This agent exhibits increased integrin receptor binding affinity, tumor cell uptake and increased radiolabeling yield as compared to the non-pegylated form (18F-FRGD2). Integrins, transmembrane glycoproteins, may be upregulated on proliferating tumor vessel endothelial cells and various cancer cells; their overexpression has been associated with neovascularization, differentiation, proliferation of tumor cells, metastasis and an overall poor prognosis.NCI
code
  • C97334
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