About: Alendronate Sodium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Alendronate Sodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Organophosphorus Compound
Preferred_Name
  • Alendronate Sodium
UMLS_CUI
  • C0700482
CAS_Registry
  • 121268-17-5
FDA_UNII_Code
  • 2UY4M2U3RA
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat certain bone conditions, such as osteoporosis and Paget disease of the bone. It is also being studied in the treatment of hypercalcemia (high levels of calcium in the blood) and bone pain caused by cancer. Fosamax slows the breakdown of bone and prevents the loss of calcium. It is a type of bisphosphonate.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41299
PDQ_Closed_Trial_Search_ID
  • 41299
Chemical_Formula
  • C4H12NO7P2.Na.3H2O
Legacy_Concept_Name
  • Alendronate_Sodium
CHEBI_ID
  • CHEBI:2566
FULL_SYN
  • Alendronic Acid Monosodium Salt TrihydrateSYNCI
  • alendronate sodiumPTNCI-GLOSSCDR0000045355
  • MK-217CNNCI
  • FosamaxPTNCI-GLOSSCDR0000579610
  • Alendronate SodiumPTNCI
  • AdronatFBNCI
  • FosamaxBRNCI
  • OnclastFBNCI
  • BinostoBRNCI
  • G-704650CNNCI
  • ALENDRONATE SODIUMPTFDA2UY4M2U3RA
  • AlendrosFBNCI
DEFINITION
  • The sodium salt of alendronate, a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity. Alendronate sodium binds to and inhibits the activity of geranyltranstransferase (farnesyl pyrophosphate synthetase), an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which is important in the process of osteoclast turnover. As a result, osteoclast activity is inhibited and bone resorption and turnover are reduced.NCI
code
  • C973
is someValuesFrom of
is Has_Salt_Form of
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