About: PI3K/mTOR Kinase Inhibitor DS-7423     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • PI3K/mTOR Kinase Inhibitor DS-7423
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • PI3K/mTOR Kinase Inhibitor DS-7423
NCI_META_CUI
  • CL429785
PDQ_Open_Trial_Search_ID
  • 701858
PDQ_Closed_Trial_Search_ID
  • 701858
FULL_SYN
  • PI3K/mTOR Kinase Inhibitor DS-7423PTNCI
  • Dual PI3 Kinase/mTOR Inhibitor DS-7423SYNCI
  • DS-7423CNNCI
DEFINITION
  • An orally bioavailable inhibitor of phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor DS-7423 inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in susceptible tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K. Consequently, this agent may potentially be more potent than an agent that inhibits either PI3K kinase or mTOR kinase.NCI
code
  • C97254
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