About: 5-Fluorouracil/Salicylic Acid Topical Solution     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • 5-Fluorouracil/Salicylic Acid Topical Solution
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • 5-Fluorouracil/Salicylic Acid Topical Solution
NCI_META_CUI
  • CL429685
PDQ_Open_Trial_Search_ID
  • 701314
PDQ_Closed_Trial_Search_ID
  • 701314
FULL_SYN
  • 5-Fluorouracil/Salicylic Acid Topical SolutionPTNCI
  • Low-dose 5-Fluorouracil/Salicylic AcidSYNCI
  • LAS 41005CNNCI
  • ActikerallFBNCI
DEFINITION
  • A topical formulation containing 0.5 % of antimetabolite 5-fluorouracil (5-FU) and 10% of salicylic acid, with potential antimitotic and keratolytic activity. Upon cutaneous application, 5-FU in the 5-fluorouracil/salicylic acid topical solution impedes pyrimidine metabolism thereby inhibiting cell growth, while the salicylic acid induces anti-inflammatory response and results in keratolytic effect. This may result in the breakdown of keratinocytes and prevent proliferation of keratinocytes locally.NCI
code
  • C97131
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