About: Vitamin K1-containing Urea Skin Cream     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Vitamin K1-containing Urea Skin Cream
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Vitamin K1-containing Urea Skin Cream
NCI_META_CUI
  • CL429409
PDQ_Open_Trial_Search_ID
  • 700245
PDQ_Closed_Trial_Search_ID
  • 700245
FULL_SYN
  • Reconval K1BRNCI
  • Vitamin K1-containing Urea Skin CreamPTNCI
DEFINITION
  • A topical cream containing urea and 0.1% vitamin K1 (phytomenadione) with topical epidermal growth factor receptor (EGFR)-activating activity. Upon application of vitamin K1-containing urea skin cream, vitamin K1 may locally activate EGFR, thereby abrogating EGFR inhibition in the skin caused by systemic EGFR inhibiting agents. This may help inhibit the acne-like skin rash induced by EGFR antagonists. EGFR, a tyrosine kinase, plays a key role in maintaining epidermal integrity.NCI
code
  • C96802
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