About: TPO Receptor Agonist ONO-7746     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • TPO Receptor Agonist ONO-7746
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • TPO Receptor Agonist ONO-7746
NCI_META_CUI
  • CL429407
PDQ_Open_Trial_Search_ID
  • 700132
PDQ_Closed_Trial_Search_ID
  • 700132
FULL_SYN
  • TPO Receptor Agonist ONO-7746PTNCI
  • ONO-7746CNNCI
DEFINITION
  • An orally available small molecule and platelet thrombopoietin (TPO) receptor (TPOR; MPL) agonist with potential megakaryopoiesis stimulating activity. Upon administration, TPOR agonist ONO-7746 binds to and stimulates TPOR, which may lead to the proliferation and differentiation of megakaryocytes. In turn, this may increase the production of blood platelets and may prevent chemotherapy induced thrombocytopenia (CIT). TPOR is a cytokine receptor and member of the hematopoietin receptor superfamily.NCI
code
  • C96800
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