About: CR2-fH Fusion Protein TT30     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CR2-fH Fusion Protein TT30
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • CR2-fH Fusion Protein TT30
NCI_META_CUI
  • CL429365
PDQ_Open_Trial_Search_ID
  • 699385
PDQ_Closed_Trial_Search_ID
  • 699385
FULL_SYN
  • CR2-fH Fusion Protein TT30PTNCI
  • TT30CNNCI
DEFINITION
  • A recombinant, chimeric human fusion protein consisting of the iC3b/C3d-binding region of human complement receptor type 2 (CR2/CD21) linked to the alternative complement pathway (ACP) inhibitory domain of human factor H (fH) (CR2-fH), with potential complement system inhibiting activity. Via its C3 binding domain, TT30 selectively binds to complement activated cell surfaces and via its fH binding domain regulates ACP activity. This suppresses excessive complement activity and may result in an inhibition of ACP-mediated hemolysis of paroxysmal nocturnal hemoglobinuria (PNH) red blood cells (RBCs) as well as preventing ACP-induced tissue damage. Factor H is a key regulator in the activation of ACP.NCI
code
  • C96740
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