About: Lymphoma TAA-specific Cytotoxic T Lymphocytes     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Lymphoma TAA-specific Cytotoxic T Lymphocytes
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Lymphoma TAA-specific Cytotoxic T Lymphocytes
NCI_META_CUI
  • CL429361
PDQ_Open_Trial_Search_ID
  • 699088
PDQ_Closed_Trial_Search_ID
  • 699088
FULL_SYN
  • Lymphoma TAA-specific Cytotoxic T LymphocytesPTNCI
DEFINITION
  • A population of autologous cytotoxic T lymphocytes (CTLs) with potential immunomodulating and antitumor activities. White blood cells are grown ex-vivo and are exposed to dendritic cells (DCs) loaded with lymphoma tumor associated antigens (TAAs); the TAA-specific CTLs are further expanded ex-vivo before being introduced into the patient. Upon infusion with TAA-specific CTLs, these CTLs may help activate tumor-specific CTL responses in the patient, thereby specifically killing TAA-expressing cancer cells and eventually inhibiting tumor cell proliferation.NCI
code
  • C96736
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