About: 2-Methoxyestradiol     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • 2-Methoxyestradiol
equivalentClass
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • 2-Methoxyestradiol
NSC_Code
  • 659853
UMLS_CUI
  • C0046319
CAS_Registry
  • 362-07-2
In_Clinical_Trial_For
  • Pathologic angiogenesis; refractory plasma cell neoplasm; stage III multiple myeloma; unspecified adult solid tumors
FDA_UNII_Code
  • 6I2QW73SR5
Contributing_Source
  • FDA
ALT_DEFINITION
  • 2ME2. A drug derived from estrogen that belongs to the family of drugs called angiogenesis inhibitors. It prevents the formation of new blood vessels that tumors need in order to grow.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38472
PDQ_Closed_Trial_Search_ID
  • 38472
Chemical_Formula
  • C19H26O3
Legacy_Concept_Name
  • _2-Methoxyestradiol
CHEBI_ID
  • CHEBI:28955
FULL_SYN
  • 2-methoxyestradiolPTNCI-GLOSSCDR0000045058
  • 2-MethoxyestradiolPTDCP07274
  • 2ME2ABNCI
  • PanzemBRNCI
  • (17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diolSNNCI
  • 2-MethoxyestradiolPTNCI
  • 2-METHOXYESTRADIOLPTFDA6I2QW73SR5
  • 2-Methoxy EstradiolSYNCI
DEFINITION
  • An orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis. (NCI04)NCI
code
  • C965
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