About: Integrin Receptor Antagonist GLPG0187

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About: Integrin Receptor Antagonist GLPG0187 Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Integrin Receptor Antagonist GLPG0187
rdfs:subClassOf	Endothelial-Specific Integrin/Survival Signaling Inhibitor nodeID://b683046 nodeID://b683047 nodeID://b683048
Has_Target	Integrin alphaVbeta3 Integrin Alpha-V Beta-5 Protein
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Integrin Receptor Antagonist GLPG0187
NCI_META_CUI	CL429007
PDQ_Open_Trial_Search_ID	697397
PDQ_Closed_Trial_Search_ID	697397
FULL_SYN	Integrin Receptor Antagonist GLPG0187PTNCI GLPG0187CNNCI
DEFINITION	A small molecule integrin receptor antagonist (IRA) with potential antineoplastic activity. Upon administration, GLPG0187 binds to and blocks the activity of 5 RGD-integrin receptor subtypes, including alphavbeta1, alphavbeta3, alphavbeta5, alphavbeta6 and alpha5beta1. This may result in the inhibition of endothelial cell-cell interactions and endothelial cell-matrix interactions, and the prevention of angiogenesis and metastasis in tumor cells expressing these integrin receptors. Integrin receptors are transmembrane glycoproteins expressed on the surface of tumor vessel endothelial cells and some types of cancer cells, and play a crucial role in endothelial cell adhesion and migration.NCI
code	C96223

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