About: Gemcitabine Hydrochloride

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Attributes	Values
rdf:type	Class
rdfs:label	Gemcitabine Hydrochloride
rdfs:subClassOf	Pyrimidine Antagonist Ribonucleotide Reductase Inhibitor nodeID://b676629 nodeID://b676630 nodeID://b676631 nodeID://b676632 nodeID://b676633
Has_Free_Acid_Or_Base_Form	GEMCITABINE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name	Gemcitabine Hydrochloride
NSC_Code	613327
UMLS_CUI	C0771488
CAS_Registry	122111-03-9
Accepted_Therapeutic_Use_For	Bladder cancer; Breast cancer; Carcinoma of unknown primary origin; Lung cancer; including non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Renal cell carcinoma
In_Clinical_Trial_For	Ovarian cancer; Osteosarcoma; Pancreatic cancer; Renal cell cancer; Salivary Gland cancer Adult Hodgkin's lymphoma; Bladder cancer; Breast Cancer; Cervical cancer; Chondrosarcoma; Ewing's sarcoma; Gallbladder cancer; Non-small cell lung cancer; Liver cancer; Meningeal Neoplasms; Mesothelioma
FDA_UNII_Code	U347PV74IL
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat pancreatic cancer that is advanced or has spread. It is also used with other drugs to treat breast cancer that has spread, advanced ovarian cancer, and non-small cell lung cancer that is advanced or has spread. It is also being studied in the treatment of other types of cancer. Gemcitabine hydrochloride blocks the cell from making DNA and may kill cancer cells.NCI-GLOSS
PDQ_Open_Trial_Search_ID	41213
PDQ_Closed_Trial_Search_ID	41213
Chemical_Formula	C9H11F2N3O4.HCl
Legacy_Concept_Name	Gemcitabine
CHEBI_ID	CHEBI:31647
FULL_SYN	2'Deoxy-2',2'-Difluorocytidine, HydrochlorideSNNCI gemcitabine hydrochloridePTNCI-GLOSSCDR0000508951 Gemcitabine HydrochloridePTNCI Difluorodeoxycytidine HydrochlorideSYNCI GemzarPTNCI-GLOSSCDR0000508952 dFdCydSYNCI GemzarBRNCI GEMCITABINE HYDROCHLORIDEPTFDAU347PV74IL 1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose, hydrochlorideSNNCI LY-188011CNNCI
DEFINITION	The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.NCI
code	C961
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