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AttributesValues
rdf:type
rdfs:label
  • Tezacitabine Anhydrous
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Tezacitabine Anhydrous
NCI_META_CUI
  • CL428311
CAS_Registry
  • 130306-02-4
FDA_UNII_Code
  • 7607Y95N9S
Contributing_Source
  • FDA
Chemical_Formula
  • C10H12FN3O4
FULL_SYN
  • Tezacitabine AnhydrousPTNCI
  • TEZACITABINE ANHYDROUSPTFDA7607Y95N9S
  • FMdC AnhydrousABNCI
  • 2'-Deoxy-2'-(fluoromethylene)cytidine AnhydrousSNNCI
DEFINITION
  • The anhydrous form of tezacitabine, a synthetic pyrimidine nucleoside analogue with potential antineoplastic activity. Phosphorylated by cellular kinases, tezacitabine is converted into its active diphosphate and triphosphate metabolites. Tezacitabine diphosphate binds to and irreversibly inhibits the activity of the enzyme ribonucleotide reductase (RNR), which may result in the inhibition of DNA synthesis in tumor cells and eventually tumor cell apoptosis. Tezacitabine triphosphate acts as a substrate for DNA polymerase, thereby further inhibiting DNA replication. RNR catalyzes the conversion of ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates, a necessary step for DNA synthesis, and is overexpressed in many tumor cell types.NCI
code
  • C95916
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