About: STAT3 Inhibitor OPB-51602     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • STAT3 Inhibitor OPB-51602
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • STAT3 Inhibitor OPB-51602
NCI_META_CUI
  • CL428286
PDQ_Open_Trial_Search_ID
  • 684303
PDQ_Closed_Trial_Search_ID
  • 684303
FULL_SYN
  • STAT3 Inhibitor OPB-51602PTNCI
  • OPB-51602CNNCI
DEFINITION
  • An orally bioavailable inhibitor of signal transducer and activator of transcription 3 (STAT3), with potential antineoplastic activity. STAT3 inhibitor OPB-51602 inhibits the phosphorylation and thus the activation of STAT3 protein, impeding STAT3 protein from translocating from the cytoplasm to the nucleus and thereby blocking STAT3's regulation of gene expression through direct binding to the promoters of responsive genes. STAT3 regulates the cellular functions that lead to the cancer phenotype, and constitutive activation of STAT3 is observed in a wide range of human cancers, inducing uncontrolled proliferation and neoplastic transformation.NCI
code
  • C95889
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