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AttributesValues
rdf:type
rdfs:label
  • siG12D LODER
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • siG12D LODER
NCI_META_CUI
  • CL428214
PDQ_Open_Trial_Search_ID
  • 685237
PDQ_Closed_Trial_Search_ID
  • 685237
FULL_SYN
  • siG12D LODERPTNCI
DEFINITION
  • A proprietary, miniature biodegradable polymeric matrix containing small-interfering RNAs for the mutated KRAS oncogene, KRASG12D, (siG12D), with potential antitumor activity. Upon intratumoral injection, this siG12D is released locally, thereby preventing translation of KRAS proteins and potentially inhibiting growth of tumor cells overexpressing KRAS. KRAS, a member of the small GTPase superfamily, is mutated in over 90% of human pancreatic ductal adenocarcinomas (PDAC) and is associated with tumor cell proliferation and reduced survival.NCI
code
  • C95772
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