About: Freeze-dried Black Raspberry Bioadhesive Gel     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Freeze-dried Black Raspberry Bioadhesive Gel
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Freeze-dried Black Raspberry Bioadhesive Gel
NCI_META_CUI
  • CL428212
PDQ_Open_Trial_Search_ID
  • 685202
PDQ_Closed_Trial_Search_ID
  • 685202
FULL_SYN
  • Freeze-dried Black Raspberry Bioadhesive GelPTNCI
DEFINITION
  • A bioadhesive gel containing 10% freeze-dried black raspberries (FBR) with potential chemopreventive and antioxidant activities. The four main constituent black raspberry anthocyanins that contribute significantly to the chemopreventive effects are cyanidin 3-glucoside (C3GLU), cyanidin 3-rutinoside (C3RUT), cyanidin 3-sambubioside (C3SAM) and cyanidin 3-(2(G)-xylosyl) rutinoside (C3XRUT). Upon mucosal application, the anthocyanins from the gel penetrate the oral mucosa and are able to modulate expression of certain proapoptotic and terminal differentiation genes, and reduce the expression of epithelial cyclooxygenase-2 (COX-2) protein. In addition, this gel may also reduce vascular densities in the superficial connective tissues.NCI
code
  • C95770
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