About: Prohibitin-Targeting Peptide 1     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Prohibitin-Targeting Peptide 1
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Prohibitin-Targeting Peptide 1
PubMedID_Primary_Reference
  • 15133506
NCI_META_CUI
  • CL428174
PDQ_Open_Trial_Search_ID
  • 691802
PDQ_Closed_Trial_Search_ID
  • 691802
FULL_SYN
  • Prohibitin-TP01SYNCI
  • TP01CNNCI
  • Prohibitin-Targeting Peptide 1PTNCI
DEFINITION
  • A chimeric, 25-mer peptide that targets prohibitin, with potential antineoplastic activity. Prohibitin-targeting peptide 1 (prohibitin-TP01) consists of a fat-targeting motif (CKGGRAKDC), two repeats of a proapoptotic peptide motif (KLAKLAK) and a GG linker. This peptide binds specifically to prohibitin in the white adipose vasculature; upon receptor-mediated cell internalization, the ligand/receptor complex triggers apoptosis and results in ablation of white fat. Destruction of white fat may potentially have positive consequences for men with prostate cancer since a high level of white fat has been implicated as a critical contributing factor in poor prostate cancer outcome. Prohibitin, a multifunctional membrane-associated protein that is thought to regulate cell survival and growth, has been shown by immunohistochemical analysis to be expressed in the membrane of endothelial cells in white adipose tissue.NCI
code
  • C95709
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