About: Saracatinib Difumarate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Saracatinib Difumarate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Saracatinib Difumarate
UMLS_CUI
  • C2987006
CAS_Registry
  • 893428-72-3
FDA_UNII_Code
  • 8R1DYT4EAW
Contributing_Source
  • FDA
Chemical_Formula
  • C27H32ClN5O5.2C4H4O4
FULL_SYN
  • Saracatinib DifumaratePTNCI
  • 4-Quinazolinamine, N-(5-Chloro-1,3-Benzodioxol-4-yl)-7-(2-(4-Methyl-1-Piperazinyl)Ethoxy)-5-((Tetrahydro-2H-Pyran-4-yl)Oxy)-, (2e)-2-Butenedioate (1:2)SNNCI
  • N-(5-Chloro-1,3-Benzodioxol-4-yl)-7-(2-(4-Methylpiperazin-1-yl)Ethoxy)-5-(Tetrahydro-2H-Pyran-4-yloxy)Quinazolin-4-Amine Di((2e)-but-2-Enedioate)SNNCI
  • SARACATINIB DIFUMARATEPTFDA8R1DYT4EAW
  • AZD0530 DifumarateCNNCI
  • AZD-0530 DifumarateCNNCI
DEFINITION
  • The difumarate salt of saracatinib, an orally available 5-, 7-substituted anilinoquinazoline with anti-invasive and anti-tumor activities. Saracatinib is a dual-specific inhibitor of Src and Abl, protein tyrosine kinases that are overexpressed in chronic myeloid leukemia cells. This agent binds to and inhibits these tyrosine kinases and affects cell motility, cell migration, adhesion, invasion, proliferation, differentiation, and survival. Specifically, Saracatinib inhibits Src kinase-mediated osteoclast bone resorption.NCI
code
  • C95224
is Has_Salt_Form of
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