About: Lutetium Lu 177-DOTA-TATE     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Lutetium Lu 177-DOTA-TATE
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Lutetium Lu 177-DOTA-TATE
PubMedID_Primary_Reference
  • 18649310
  • 20168290
NCI_META_CUI
  • CL426555
PDQ_Open_Trial_Search_ID
  • 689409
PDQ_Closed_Trial_Search_ID
  • 689409
FULL_SYN
  • lutetium Lu 177-DOTATATESYNCI
  • Lutetium Lu 177-DOTA-TATEPTNCI
  • Lutetium Lu 177-DOTA-Tyr3-OctreotateSYNCI
  • 177 Lu-DOTA-TATEABNCI
  • 177 Lu-DOTA-Tyr3-OctreotateSYNCI
DEFINITION
  • A radioconjugate consisting of the tyrosine-containing somatostatin analog Tyr3-octreotate (TATE) conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and radiolabeled with the beta-emitting radioisotope lutetium Lu 177 with potential antineoplastic activities. Lutetium Lu 177-DOTA-TATE binds to somatostatin receptors (SSTRs), with high affinity to type 2 SSTR, present on the cell membranes of many types of neuroendocrine tumor (NET) cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to SSTR-positive cells. Tyr3-octreotate (TATE) is an octreotide derivative in which phenylalanine at position 3 is substituted by tyrosine and position 8 threoninol is replaced with threonine. SSTRs have been shown to be present in large numbers on NET and their metastases, while most other normal tissues express low levels of SSTRs.NCI
code
  • C95020
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