About: Zidovudine

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Zidovudine
rdfs:subClassOf	Pyrimidine Antagonist Nucleoside Reverse Transcriptase Inhibitors
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name	Zidovudine
NSC_Code	602670
UMLS_CUI	C0043474
CAS_Registry	30516-87-1
Accepted_Therapeutic_Use_For	AIDs-related complex; HIV infection; HIV transmission, prevention
In_Clinical_Trial_For	AIDs-related primary CNS lymphoma; Castleman's disease associated with KSAH; HIV infections; HTLV-1-related T-cell leukemia and lymphoma
FDA_UNII_Code	4B9XT59T7S
Contributing_Source	FDA
ALT_DEFINITION	A drug that inhibits the human immunodeficiency virus (HIV) that causes AIDS. It is a type of systemic antiviral.NCI-GLOSS
PDQ_Open_Trial_Search_ID	40121
PDQ_Closed_Trial_Search_ID	40121
Chemical_Formula	C10H13N5O4
Legacy_Concept_Name	Zidovudine
CHEBI_ID	CHEBI:10110
FULL_SYN	AZTPTNCI-GLOSSCDR0000044478 zidovudinePTNCI-GLOSSCDR0000045286 1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)-5-methylpyrimidine-2,4-(1H,3H)-dioneSNNCI AzidothymidineSYNCI AZTABNCI ZDVABNCI 3'-Azido-3'-deoxythymidineSNNCI AzidothymidineSYDTPNSC0602670 AztecFBNCI RetrovirSYDTPNSC0602670 DRG-0004CNNCI BW A509UCNNCI ZIDOVUDINEPTFDA4B9XT59T7S BW-A509UCNNCI RetrovirBRNCI BW-A 509UCNNCI ZidovudineSYDTPNSC0602670 Compound SSYNCI 3'-Azido-3'-deoxythymidineSYDTPNSC0602670 ZidovudinePTNCI
DEFINITION	A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines. (NCI04)NCI
code	C947
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