About: E. coli CD-expressing Genetically Modified Neural Stem Cells     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • E. coli CD-expressing Genetically Modified Neural Stem Cells
rdfs:subClassOf
Semantic_Type
  • Cell
  • Pharmacologic Substance
Preferred_Name
  • E. coli CD-expressing Genetically Modified Neural Stem Cells
NCI_META_CUI
  • CL421632
PDQ_Open_Trial_Search_ID
  • 680811
PDQ_Closed_Trial_Search_ID
  • 680811
FULL_SYN
  • E. coli CD-expressing Genetically Modified Neural Stem CellsPTNCI
DEFINITION
  • Genetically-modified neural stem cells (NSCs) transfected with the Escherichia coli (E. coli) suicidal gene cytosine deaminase (CD), with potential antineoplastic adjuvant activity. Upon intracerebral injection, E. coli CD-expressing genetically modified NSCs express the E. coli cytosine deaminase, an enzyme that catalyzes the intracellular conversion of the nontoxic prodrug 5-fluorocytosine (5-FC) into the cytotoxic 5-fluorouracil (5-FU). Co-administration of this agent with 5-FC and upon local activation of 5-FU in the brain tumor, 5-FU disrupts DNA synthesis in tumor cells thereby impeding cellular proliferation with minimal systemic exposure and toxicity.NCI
code
  • C92585
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